郭建全

男，漢族，1985年05月出生，講師。長期從事癌癥治療相關(guān)的醫(yī)藥技術(shù)研究。在挖掘癌癥治療靶點的同時，將納米醫(yī)藥技術(shù)和合成生物學(xué)技術(shù)與癌癥的預(yù)防和治療有效結(jié)合，利用組蛋白仿生藥物遞送系統(tǒng)進行癌癥治療，相關(guān)成果發(fā)表于Bioactive Materials（Top一區(qū)，18.9）；同時利用微生物作為底盤細胞進行藥物合成以及遞送研究。截止目前主持山西省自然科學(xué)基金2項，山西省高等學(xué)?？萍即蔥祿鶼钅?項，山西省博士后基金1項，并作為骨干成員參與國家自然科學(xué)基金等各類基金多項。以第一或通訊作者發(fā)表SCI論文10篇。

教育經(jīng)歷

2011.09-2016.03哈爾濱工業(yè)大學(xué)，生物醫(yī)學(xué)工程，博士

2008.09-2011.06東北農(nóng)業(yè)大學(xué)，應(yīng)用微生物，碩士

2004.09-2008.06濰坊學(xué)院，生物科學(xué)，學(xué)士

工作經(jīng)歷

2016.03-至今 c7c7.app公共衛(wèi)生學(xué)院，衛(wèi)生檢驗與檢疫教研室

學(xué)習(xí)經(jīng)歷

2018.06-2023.05，c7c7.app第一臨床醫(yī)學(xué)院博士后工作站，博士后

教學(xué)情況

全國高質(zhì)量醫(yī)學(xué)教師教學(xué)發(fā)展在線課程負責(zé)人，山西省一流精品認定課程負責(zé)人，c7c7.app思政示范課程負責(zé)人，主持山西省教育改革課題1項，c7c7.app教改課題2項，榮獲第四屆全國高校混合式教學(xué)設(shè)計創(chuàng)新大賽一等獎；全國衛(wèi)生檢驗與檢疫專業(yè)青年教師教學(xué)技能大賽二等獎和優(yōu)秀教案獎；山西省教師教學(xué)創(chuàng)新大賽二等獎；c7c7.app《免疫學(xué)檢驗》課程混合式教學(xué)設(shè)計一等獎；c7c7.app教師教學(xué)創(chuàng)新大賽一等獎；c7c7.app優(yōu)秀教師等。主要承擔(dān)本科生《免疫學(xué)檢驗》、《衛(wèi)生微生物學(xué)》、《細菌學(xué)檢驗》等課程。

代表性科研項目

1山西省科技廳,山西省應(yīng)用基礎(chǔ)研究，202203021211244, Msi-1在去勢抵抗性前列腺癌異常糖代謝中的調(diào)控作用和分子機制研究, 2023-01至2025-12, 8萬元,在研,主持。

2山西省人社廳,博士后專項,晉人社廳函[2020]1015號,聯(lián)合¹⁸F-FDG PET顯像探究Msi1靶向HIF-1α增強前列腺癌骨轉(zhuǎn)移的機制, 2021-01至2023-06, 14萬元, 結(jié)題,主持。

3山西省教育廳,山西省高等學(xué)校科技創(chuàng)新項目, 2019L0419, Musashai1靶向TGF-β信號通路促進去勢誘導(dǎo)的EMT的機制研究, 2019-07至2022-06, 2萬元,結(jié)題,主持。

4山西省科技廳,山西省應(yīng)用基礎(chǔ)研究，201801D221396,雄激素/AR/miR-101軸靶向Msi1負調(diào)控ADT誘導(dǎo)EMT的機制研究, 2018-12至2020-12, 3萬元,結(jié)題,主持。

代表性論著：*代表通訊作者

(1) Bangyuan Zhou; Yali Niu; Dan Wang; Liangpo Liu; Jianquan Guo*; Geraniol alleviates liver injury induced by bisphenol A via modulating NLRP3/caspase 1 pathway and gut microbiota in mice model. Food Science and Biotechnology (2024) 33:3119–3130.（中科院分區(qū)3區(qū)，IF:3.2）

(2)Jianquan Guo，Liyang Yang. Regulation effect of the intestinal flora and intervention strategies targeting the intestinal flora in alleviation of pulmonary fibrosis development. Biosci Microbiota Food Health 2024;43(4):293-299.（中科院分區(qū)4區(qū)，IF:3.1）

(3) Liyang, Yang; Yali, Niu;Jianquan Guo*. Un-avoided polycyclic aromatic hydrocarbons exposure on human and animals: current detoxication strategies and future prospects. Int J Environ Health Res 2024 Nov 20;0(0):1-14.（中科院分區(qū)4區(qū)，IF:2.3）

(4)Jianquan, Guo; Bangyuan, Zhou; Yali, Niu; Liangpo, Liu; Liyang, Yang. Engineered probiotics introduced to improve intestinal microecology for the treatment of chronic diseases: present state and perspectives.J Diabetes Metab Disord 2023 Dec;22(2):1029-1038.（中科院分區(qū)4區(qū)，IF:1.8）

(5)Guo Jianquan; Tan Dongsheng; Lou Chenmei; Guo Shiying; Jin Xing; Qu Haijing; Jing Lijia; Li Sijin ; A tumor-penetrable drug nanococktail made from human histones for interventional nucleus-targeted chemophotothermal therapy of drug-resistant tumors, Bioactive Materials, 2022, 9: 554-565.（中科院分區(qū)1區(qū)Top，IF:18.9）

(6) Li Yang, Yang; Qiang, Gong;Jianquan, Guo*; Gui Lan, Li*. Microbes as a production host to produce natural activecompounds from mushrooms: biosynthetic pathway elucidationand metabolic engineering. Chin J Nat Med. 2021 Aug;19(8):580-590.（中科院分區(qū)2區(qū)，IF:5.2）

(7)Guo, Jianquan*; Feng, Shengwen; Cheng, Xiaoyu ; Activity evaluation of glycolytic promoters from Escherichia coli and application for mevalonate biosynthesis, Journal of Microbiological Methods, 2020, 174.（中科院分區(qū)4區(qū)，IF:2.0）

(8) Yang, Liyang; Li, Guilan; Chai, Zhi; Gong, Qiang;Guo, Jianquan* ; Synthesis of cordycepin: Current scenario and future perspectives, Fungal Genetics and Biology, 2020, 143.（中科院分區(qū)3區(qū)，IF:3.0）

(9)Guo, Jianquan; Mei, Yu; Li, Kai; Huang, Xuemei; Yang, Huanjie ; Downregulation of miR-17-92a cluster promotes autophagy induction in response to celastrol treatment in prostate cancer cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 478(2): 804-810.（中科院分區(qū)3區(qū)，IF:3.1）

(10)Guo, Jianquan; Huang, Xuemei; Wang, Hui; Yang, Huanjie ; Celastrol Induces Autophagy by Targeting AR/miR-101 in Prostate Cancer Cells., PLoS One, 2015, 10(10): e0140745-e0140745.（中科院分區(qū)3區(qū)，IF:3.1）

(11) Ben, Li; Ting, Liu; Yongmei, Shen; Jiangnan, Qin; Xiaohan, Chang; Meiqiong, Wu; Jianquan, Guo;Liangpo, Liu; Cailing, Wei; Yi, Lyu; Fengjie, Tian; Jinzhu, Yin; Tong, Wang; Wenping, Zhang; Yulan, Qiu.TFEB/LAMP2 contributes to PM(0.2)-induced autophagy-lysosome dysfunction and alpha-synuclein dysregulation in astrocytes.J Environ Sci (China) 2024 Nov;145(0):117-127.（中科院分區(qū)2區(qū)，IF:5.9）

(12) Liping, Liu; Tiedong, Sun; Feng, Xin; Wei, Cui; Jianquan, Guo; Jian, Hu. Nerve Growth Factor Protects Against Alcohol-Induced Neurotoxicity in PC12 Cells via PI3K/Akt/mTOR Pathway. Alcohol Alcohol 2017 Jan;52(1):12-18.（中科院分區(qū)4區(qū)，IF:2.0）

(13) Liangpo, Liu; Peixia, Yan; Jifang, Lv; Xuan, Liu; Junxia, Zhao; Jianquan, Guo; Guiying, Liu; Xia, Bian; Linying, Gao; Wei, Yan; Qiansheng, Huang; Guixia, Chen. Optimization and application of a method to determine 24 perfluorinated compounds in umbilical cord serum by using liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2022 Sep 1;1207(0):123365.（中科院分區(qū)3區(qū)，IF:3.0）

(14)Liangpo, Liu; Peixia, Yan; Xuan, Liu; Junxia, Zhao; Meiping, Tian; Qingyu, Huang; Jianbo, Yan; Zhendong, Tong; Yongli, Zhang; Jie, Zhang; Tongjie, Zhang; Jianquan, Guo; Guiying, Liu; Xia, Bian; Ben, Li; Tong, Wang; Heng, Wang; Heqing, Shen. Profiles and transplacental transfer of per- and polyfluoroalkyl substances in maternal and umbilical cord blood: A birth cohort study in Zhoushan, Zhejiang Province, China. J Hazard Mater 2024 Mar 15;466(0):133501J Hazard Mater 2024 Mar 15;466(0):133501.（中科院分區(qū)1區(qū)Top，IF:12.2）

(15) Ben, Li; Xiaohan, Chang; Xiaomin, Liang; Ting, Liu; Yongmei, Shen; Qianwen, Zhang; Xiaohui, Yang; Yi, Lyu; Liangpo, Liu; Jianquan, Guo; Meiqiong, Wu; Yi, Gao; Xiaoyan, Yan; Tong, Wang; WenPing, Zhang; Yulan, Qiu; JinPing, ZhengThe role of reactive astrocytes in neurotoxicity induced by ultrafine particulate matter. Sci Total Environ 2023 Apr 1;867(0):161416.（中科院分區(qū)1區(qū)Top，IF:8.1）