張紅梅

博士，教授，博士生導師，博士后合作指導教師，實驗教學中心主任

Phone（O）：0351-4135273

Email：hm.zhang@sxmu.edu.cn,zhhm_108@163.com

通信地址： c7c7.app公共衛(wèi)生學院，山西省太原市新建南路56號，030001

教育經(jīng)歷：

2003/09-2008/07，c7c7.app，勞動衛(wèi)生與環(huán)境衛(wèi)生學，博士

1998/09-2003/07，c7c7.app，預防醫(yī)學，學士

工作經(jīng)歷：

2020/06-至今，c7c7.app公共衛(wèi)生學院實驗教學中心，主任

2019/01-至今，c7c7.app環(huán)境衛(wèi)生學教研室，教授

2010/07-2018/12，c7c7.app環(huán)境衛(wèi)生學教研室，副教授

2008/09-2010/06，c7c7.app環(huán)境衛(wèi)生學教研室，講師

學習經(jīng)歷：

2013/12-2014/12，美國辛辛那提大學醫(yī)學院，訪問學者

學術(shù)任職：

中國環(huán)境誘變劑學會環(huán)境與神經(jīng)退行性疾病委員會委員，中國環(huán)境誘變劑學會生物標志物委員會青年委員，國家醫(yī)師資格考試公共衛(wèi)生類別試題開發(fā)專家委員會委員，中華預防醫(yī)學會環(huán)境衛(wèi)生分會青年委員，中華醫(yī)學會公共衛(wèi)生分會第十屆委員會青年委員會委員，山西省青年科技人才協(xié)會生物與醫(yī)藥科學專業(yè)委員會常務(wù)理事，山西省優(yōu)生科學協(xié)會常務(wù)委員，山西省科技廳專家，中國毒理學會會員，中國環(huán)境科學學會會員，山西省環(huán)境誘變劑學會會員，Human and experimental toxicology，Molecular Neurobiology等雜志的審稿人。

榮譽稱號：

山西省高等學校優(yōu)秀青年學術(shù)帶頭人（2011），山西省高等學校“131領(lǐng)軍人才工程”優(yōu)秀中青年拔尖創(chuàng)新人才（2013），山西省“三晉英才”青年優(yōu)秀人才（2018），第19屆山西青年五四獎?wù)芦@得者。

教學情況：

為預防醫(yī)學、臨床醫(yī)學、衛(wèi)生檢驗檢疫專業(yè)及醫(yī)學相關(guān)專業(yè)本科生講授《環(huán)境衛(wèi)生學》、《預防醫(yī)學》、《環(huán)境生物學》、《水質(zhì)理化檢驗》、《公共衛(wèi)生基本操作技能》等課程，為公共衛(wèi)生研究生講授《環(huán)境醫(yī)學概論》。負責1門校級精品課程，主持校級教改項目3項，指導1項大學生創(chuàng)新創(chuàng)業(yè)校級項目，發(fā)表教學論文2篇，參與獲得山西省教學成果獎（高等教育）二等獎1項。

研究領(lǐng)域：

1.環(huán)境和職業(yè)污染物的神經(jīng)毒性；

2.職業(yè)人群的暴露監(jiān)測與健康效應(yīng)研究；

已指導全日制研究生16名，非全日制研究生7名，指導的碩士學位論文被評為山西省優(yōu)秀碩士學位論文。近10年在國內(nèi)核心期刊發(fā)表科研論文61篇，其中SCI收錄論文16篇，累計影響因子為67，其中Top 1區(qū)2篇，2區(qū)8篇，論文單篇IF 9.776。

科研獲獎：

獲得山西省科學技術(shù)一等獎1項，中華預防醫(yī)學會科學技術(shù)三等獎1項，中國金屬學會冶金醫(yī)學二等1項。

代表性科研項目：

1.國家自然科學基金面上基金項目，81973093，小膠質(zhì)細胞極化-BDNF甲基化介導的突觸重構(gòu)在苯并[a]芘致認知功能障礙中的調(diào)控機制，2020/01-2023/12，主持

2.國家自然科學基金青年基金項目，81001258，ROS反饋環(huán)在哺乳期PBDEs暴露致大鼠神經(jīng)發(fā)育毒性的機制研究，2011/01-2013/12，主持

3.山西省留學人員科技活動擇優(yōu)資助項目，2019028，小膠質(zhì)細胞活化和極化調(diào)控的突觸重構(gòu)在苯并[a]芘致認知功能障礙中的機理研究，2019/07-2022/12，主持

4.山西省回國留學人員科研資助項目，2017-059，DNMTs-BDNF基因甲基化修飾在苯并[a]芘致認知功能損傷中的調(diào)控作用，2017/07-2020/07，主持

5.山西省基礎(chǔ)研究計劃項目，2013021033-3，多溴聯(lián)苯醚神經(jīng)發(fā)育毒性的體內(nèi)實驗研究，2013/01-2015/12，主持

代表性論著：

1.Hongmei Zhang#, Xiaorong Yang#, Xin Li, Yan Cheng, Huajun Zhang, Lijun Chang, Min Sun, Zhihong Zhang, Zemin Wang, Qiao Niu*, Tong Wang*. Oxidative and nitrosative stress in the neurotoxicity of polybrominated diphenyl ether-153: possible mechanism and potential antioxidation targeted intervention. Chemosphere, 2020, 238(2020) : 1-13 (1區(qū)，IF=5.778) [PMID: 31545211]

2.Zhenzhen Xu#, Hongyan Wu#,Hongmei Zhang, Jianying Bai, Zhihong Zhang*. Interleukins 6/8 and cyclooxygenase-2 release and expressionsare regulated by oxidative stress-JAK2/STAT3 signalingpathway in human bronchial epithelial cells exposed to particulate matter≤2.5μm. J Appl Toxicol. 2020; 1-9. (3區(qū)，IF=2.997)[PMID: 32212198]

3.Xin Li, Xiaorong Yang, Lijun Chang, Zemin Wang, Tong Wang, Zhihong Zhang, Jianying Bai, Ruifeng Liang, Qiao Niu,Hongmei Zhang*. Endoplasmic reticulum rather than mitochondria plays a major role in the neuronal apoptosis induced by polybrominated diphenyl ether-153. Toxicology Letters, 2019, 311(2019):37-48. (2區(qū)，IF=3.360) [PMID: 31029751]

4.Xiaorong Yang#*,Hongmei Zhang#, Jinzi Wu, Litian Yin, Liang-Jun Yan, Ce Zhang*. Humanin attenuatesNMDA-induced excitotoxicity by inhibiting ROS-dependent JNK/p38 MAPK pathway. International Journal of Molecular Sciences. 2018, 19, 2982: 1-12.（3區(qū)，IF=3.687）[PMID: 30274308]

6.Hongmei Zhang#, Xiaorong Yang#, Huajun Zhang, Xin Li, Zhihong Zhang, Lifang Hou, Zemin Wang,Qiao Niu*, Tong Wang*. Neurotrophins and cholinergic enzyme regulated by calpain-2: new insights into neuronal apoptosis induced by polybrominated diphenyl ether-153. Toxicology Letters, 2018, 291(2018): 29-38. (2區(qū)，IF=3.858). [PMID: 29621559]

7.Guofang Lu#, Jianguo Li,Hong-Mei Zhang, Xin Zhao, Liang-Jun Yan, Xiaorong Yang*.Role and possible mechanisms of Sirt1 in depression. Oxidative Medicine and Cellular Longevity. 2018, 2018:1-6. (2區(qū)，IF=4.593) . [PMID: 29643977]

8.Hongmei Zhang#, Kimberly Yolton, Glenys M. Webster, Xiaoyun Ye, Antonia M. Calafat, Kim N. Dietrich, Yingying Xu, Changchun Xie, Joseph M. Braun, Bruce P. Lanphear, Aimin Chen*. Prenatal and childhood perfluoroalkyl substances exposures and children's reading skills at ages 5 and 8 years. Environment International, 2018, 111: 224-231. (Top 1區(qū)，IF=7.088) [PMID: 29241079]

9.Hongmei Zhang#*, Lijun Chang, Huajun Zhang, Jisheng Nie, Zhihong Zhang, Xiaorong Yang, Ann M.Vuong, Zemin Wang, Aimin Chen, Qiao Niu. Calpain-2/p35-p25/Cdk5 pathway is involved in the neuronal apoptosis induced by polybrominated diphenyl ether-153. Toxicology Letters, 2017, 277(2017):41-53. (2區(qū)，IF=3.858). [PMID: 28559121]

10.Hongmei Zhang#, Kimberly Yolton, Glenys M. Webster, Andreas Sj?din, Antonia M. Calafat, Kim N. Dietrich, Yingying Xu, Changchun Xie, Joseph M. Braun, Bruce P. Lanphear, Aimin Chen*. Prenatal PBDE and PCB exposures and reading, cognition, and externalizing behavior in children.Environmental Health Perspectives. 2017, 125(4): 746-752. (Top 1區(qū)，IF=9.776). [PMID: 27385187]

11.Hongmei Zhang#*, Xin Li, Liping Ge, Jin Yang, Sun Jianya, Qiao Niu. Methylation of CpG island of p14(ARK), p15(INK4b) and p16(INK4a) genes in coke oven workers. Human and Experimental Toxicology. 2015, 34(2): 191-197(4區(qū)，IF=1.747).

12.Nie Ji-Sheng#,Zhang Hong-Mei, Zhao Jie, Liu Hui-Jun, Niu Qiao*.Involvement of mitochondrial pathway in benzo[a]pyrene-induced neuron apoptosis.Human and Experimental Toxicology. 2014, 33(3):240-250. (4區(qū)，IF=1.453).

13.Hong-Mei Zhang*, Xin Li, Ji-Sheng Nie, Qiao Niu. Lactation exposure to BDE-153 damages learning and memory, disrupts spontaneous behavior and induces hippocampus neuron death in adult rats. Brain Research, 2013, 1517: 44-56. (3區(qū), IF=2.879).

14.Hong-Mei Zhang#, Ji-Sheng Nie, Xin Li, Qiao Niu*. Association of aryl hydrocarbon receptor gene polymorphism with the neurobehavioral function and autonomic nervous system function changes induced by benzo[a]pyrene exposure in coke oven workers. Journal of Occupational and Environmental Medicine. 2013, 55(3): 265-271 (4區(qū)，IF=2.062).

15.Hong-Mei Zhang#, Ji-Sheng Nie, Xin Li, Qiao Niu*. Characteristic analysis of peripheral blood mononuclear cell apoptosis in coke oven workers. Journal of Occupational Health. 2012, 54(1): 44-50. (4區(qū)，IF=1.634). [PMID: 22186298]

16.Qiao Niu#*,Hong-Mei Zhang, Xin Li, Meiqin Li. Benzo[a]pyrene-induced neurobehavioral function and neurotransmitter alterations in coke oven workers. Occupational and Environmental Medicine. 2010, 67(7): 444-448. (2區(qū)，IF=3.494)

17.Hong-Mei Zhang#, Ji-Sheng Nie, Fang Wang, Ying-Tao Shi, Ling Zhang, Andrea Antonucci, Hui-Jun Liu, Jing Wang, Jie Zhao, Qin-Li Zhang, Lin-Ping Wang, Jing Song, Cui-E Xue, Mario Di Gioacchino, Qiao Niu*. Effects of benzo[a]pyrene on autonomic nervous system of coke oven workers. Journal of Occupational Health. 2008, 50(4): 308-316. (4區(qū)，IF=1.848)

18.孫敏, 李歡, 周小玲, 王旭紅, 聶會祥, 李新,張紅梅*.焦爐工人尿酚水平與血生化指標的關(guān)系. 中華勞動衛(wèi)生職業(yè)病雜志, 2020, 38(6): 440-443.

19.李歡, 孫敏, 曹晶晶, 劉愛香,張紅梅*.苯并[a]芘致小鼠認知功能障礙及腦細胞中miRNA的表達. 環(huán)境與健康雜志, 2019, 36(4): 320-323.