出 生 年

1972-3

系/教研室

生物化學與分子生物學

職    稱

教授

職    務

教務部副部長

導師類型

博導

最高學歷/學位/畢業院校

博士研究生/中國協和醫科大學

E-mail

ruiguo@sxmu.edu.cn

學科專業

生物化學與分子生物學

研究方向

新型醫用生物材料的研發與應用

工作單位

c7c7.app教務部

人才稱號/學術兼職

山西省學術技術帶頭人

山西省“131”領軍人才工程優秀中青年拔尖創新人才

山西省高等學校優秀青年學術帶頭人

中國生物化學與分子生物學會理事

中國生物化學與分子生物學會教學專業委員會青委會委員

山西省生物化學與分子生物學會副理事長

學習工作經歷

1994-09 ~ 1997-07：c7c7.app免疫學專業碩士研究生

1997-09 ~ 1999-06：c7c7.app基礎醫學院生物化學與分子生物學教研室助教

1999-07 ~ 2004-06：c7c7.app基礎醫學院生物化學與分子生物學教研室講師

2001-09 ~ 2004-07：中國協和醫科大學細胞生物學專業博士研究生

2004-07 ~ 2009-06：c7c7.app基礎醫學院生物化學與分子生物學教研室副教授

2005-11 ~ 2006-10：瑞典Karolinska   Institutet博士后

2009-07 ~ 今：c7c7.app基礎醫學院生物化學與分子生物學教研室教授

主持的科研

/教學項目

負載anti-miR-130a二氧化錳納米載體靶向抑制卵巢癌的實驗研

究（20210302123322）

搭載白楊素的氧化石墨烯與金納米粒子結合調節let-7a 誘導舌鱗癌細胞凋亡的研究（CPOF202307）

臨床執業能力知識圖譜課程群的建設及效果調查（24YJ0407）

聚焦兆泰書院智慧教學重構基礎醫學核心課程——以能力提升為支點探討卓越醫師的素質培養（J2020096）

互聯網+混合式教（導）-學模式構建基礎醫學線上線下混合式金課研究（J2019074）

代表性成果

（論文/專利/專著等）

1. Tao Gong, Ruolan Feng, Huirui Zhu, Moxuan Zhao, Baofeng Yu, Na Wang^*, Hongqin Wang^*, Rui Guo^*. Multi-functional poly(N-isopropylacrylamide)-based hydrogel with hemostasis, antibacterial, and sustained drug release properties for infected wound treatment. Colloids and Surfaces B: Biointerfaces, 2025, 257: 115147.

2. Yijie Wang, Ruolan Feng, Meijuan Shi, Huirui Zhu, Moxuan Zhao, Jinyu Li, Hongqin Wang, Xiaoning Li^*, Tao Gong^*, Rui Guo^*. Composites of graphene oxide and gold Nanospheres: A dual-targeted Recognition and dual-responsive release Chemophotothermal therapeutic platform. Advanced Powder Technology, 2025, 36(6).

3. Huirui Zhu, Ruolan Feng, Dongkun Li, Meijuan Shi, Nan Wang, Yijie Wang, Yumeng Guo, Xiaoning Li^*, Tao Gong^*, Rui Guo^*. A multifunctional graphene oxide-based nanodrug delivery system for tumor targeted diagnosis and treatment under chemotherapy-photothermal-photodynamic synergy. Colloids and Surfaces B: Biointerfaces, 2025, 248, 114479.

4. Di Zhang, Wanyu Wei, Tianxiang Xie, Xue Zhou, Xu He, Jie Qiao, Rui Guo^*, Gang Jin^*, Ningbo Li^*. Magnetic Nanocarriers for pH/GSH/NIR Triple-Responsive Drug Release and Synergistic Therapy in Tumor Cells. ACS Omega, 2024, 9(50): 49749-49758.

5. Xue Zhou, Xu He, Zhiying Dong, Yuxin Wang, Chuqian Hu, Di Zhang, Rui Guo^*, Jie Qiao^*, Ningbo Li^*. Manganese-Doped Mesoporous Magnetic Nanocarriers for Cancer Treatment. ACS Applied Nano Materials, 2024, 7(6): 6339-6350.

6. Kaili Qin, Yingzhu Zhao, Yuqi Zhang, Huirui Zhu, Bingmei Chang, Xiang Zhai, Xiaoyu Wang^*, Tao Gong^*, and Rui Guo^*. Methotrexate and triformyl cholic acid functionalized magnetic graphene oxide nanocomposite for multi-targeting chemo-photothermal therapy of hepatocellular carcinoma. Journal of Materials Science, 2024, 1-18.

7. Tao Gong, Qing Ma, Kaili Qin, Lingxi Wei, Chaochao Wen, Huirui Zhu, Xiaoning Li, Bingmei Chang, Wenting Liang^* and Rui Guo^*. Chemical and photothermal synergistic antimicrobial treatment for enhanced wound healing based on light/pH responsive nanocomposites. New J. Chem., 2024, 48(31): 13825-13833.

8. Xiaoning Li, Yumeng Guo, Zihan Xing, Tao Gong, Lijun Yang, Tao Yang, Bingmei Chang, Xiaoxia Wang, Baofeng Yu^*, Rui Guo^*. ABT-737 increases cisplatin sensitivity through the ROS-ASK1-JNK MAPK signaling axis in human ovarian cancer cisplatin-resistant A2780/DDP cells. Oncol Rep, 2024, 52(3): 122.

9. Xiaoning Li, Huirui Zhu, Zihan Xing, Tao Gong^*, Meining Li, Dan Su, Wenting Liang^* and Rui Guo^*. Linear maltodextrin polymer-folic acid modified graphene oxide nanoparticles for targeted delivery and pH/photothermal sensitive release of hydrophobic anticancer drugs in tumor cells. New J. Chem., 2023, 47(3): 1117-1128.

10. Tao Gong, Xiaoyu Wang, Huirui Zhu, Chaochao Wen, Qing Ma, Xiaoning Li, Meining Li, Rui Guo^*, Wenting Liang^*. Folic acid-maltodextrin polymer coated magnetic graphene oxide as a NIR-responsive nano-drug delivery system for chemo-photothermal synergistic inhibition of tumor cells. RSC Adv., 2023, 13(18): 12609-12617.

11. Xiang Zhai, Xinyang Li, Yujing Wang, Keru Qin, Jinrui Hu, Meining Li, Hailong Wang^*, Rui Guo^*. Fancd2os Reduces Testosterone Production by Inhibiting Steroidogenic Enzymes and Promoting Cellular Apoptosis in Murine Testicular Leydig Cells. Endocrinol Metab (Seoul). 2022, 37(3): 533-546.

12. Xiaoyu Wang, Qing Ma, Chaochao Wen, Tao Gong^*, Jing Li, Wenting Liang^*, Meining Li, Yuyao Wang, Rui Guo^*. Folic acid and deoxycholic acid derivative modified Fe₃O₄ nanoparticles for efficient pH-dependent drug release and multi-targeting against liver cancer cells. RSC Adv., 2021, 11(63): 39804-3981211.

13. Tao Gong, Xiaoyu Wang, Qing Ma, Jing Li,Meining Li, Yu Huang, Wenting Liang^*, Dan Su, Rui Guo^*. Triformyl cholic acid and folic acid functionalized magnetic graphene oxide nanocomposites: Multiple-targeted dual-modal synergistic chemotherapy/photothermal therapy for liver cancer. Journal of Inorganic Biochemistry, 2021, 223, 111558.

14. Tao Gong, Rina Cheng, Xiaoyu Wang, Jing Li, Wenting Liang^*, Zhihong Wei, Shaomin Shuang^*, Yuyao Wang, Rui Guo^*. Supramolecular-interaction-mediated aggregation of anticarcinogens on triformyl cholic acid-functionalized Fe₃O₄ nanoparticles and their dual-targeting treatment for liver cancer. New J. Chem., 2021, 45, 6880-6888.

一種發育階段特異性生精細胞玻片的制備方法

獲獎及個人榮譽

科技進步二等獎（自然科學類）

山西省教學成果（高等教育）一等獎

國家級一流線上線下混合式課程

首屆全國高校教師教學創新大賽山西賽區二等獎

山西省教學名師

省高等學校教學競賽一等獎（榮立一等功）

省教科文衛體系統五一勞動獎章

山西省十佳中青年優秀科技工作者

山西省優秀科技工作者

研究生培養

3名博士生

30名碩士生