我單位牛僑老師完成的“鋁作業工人認知功能損害的職業人群調查和毒作用機制實驗研究”項目擬申報2023年中華預防醫學會科學技術獎,特進行公示。公示期: 2023 年 4 月 14 日至 2023 年 4 月 20 日,公示期內如對公示內容有異議,請您向c7c7.app科學技術部反映。
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2023年4月14日
附:公示內容
一、項目名稱:鋁作業工人認知功能損害的職業人群調查和毒作用機制實驗研究
二、推薦單位及推薦意見:
推薦單位:c7c7.app
推薦意見:眾所周知,鋁在人們日常生活中用途廣泛,用量極大。本項目著眼于中國鋁生產量大、用鋁量大的基本國情,著重研究鋁對鋁作業工人的損傷,保護鋁作業工人身體健康,為制定鋁作業工人的職業病篩查標準具有重大意義。該項目研究發現的鋁導致神經細胞程序性壞死為全球首次,具有重大創新性與先進性。發現的鋁導致工人視空間記憶能力下降為職業損傷判斷標準提供了依據,因此該項目的研究成果具有重大現實意義。該項目多篇論文發表于Q1與Q2分區的高水平學術雜志,其研究成果輻射了全球多個國家和地區,對該行業有一定的影響力,有助于該領域的科技進步。
三、項目簡介:(項目簡要介紹,技術路線,創新點及項目產出。)
鋁是地殼含量豐富的金屬元素,僅次于類金屬硅,用途廣泛,用量極大。我國已經連續十余年是世界上最大的鋁生產國和使用國,據國際鋁組織(www.world-aluminium.org/)統計,我國僅2019年5月-2021年5月金屬鋁產量占全球產量57.1%,達13595.5萬噸,鋁生產直接從業者達400萬,職業暴露人口眾多。鋁具有神經毒性,被認為與認知功能損害甚至與阿爾茲海默病有關,但尚缺乏有力證據。本項目基于鋁暴露職業人群,進行了多次大人群流行病學調查,證實了職業性鋁暴露確實引起工人認知功能下降,而且與血鋁水平相關。基于本團隊對鋁的神經毒性作用機制的科學假設,我們進行了系統的實驗研究,多手段、多方位、多角度闡明了鋁的神經毒性作用機制;又將毒作用機制中的某些環節在職業人群研究中加以驗證。在前期研究(2000-2009)的基礎上,本項目基本闡述清楚了鋁的神經毒作用機制,主要從職業鋁暴露人群發現認知功能損害和血液淋巴細胞tau蛋白過度磷酸化,再進行大人群研究驗證鋁致多領域認知功能損害,發現鋁暴露水平和認知功能損害的劑量反應關系,血液中鋁濃度升高的同時鋅濃度降低,并且發現職業鋁暴露人群血液淋巴細胞全基因組甲基化降低。在實驗室研究中著重探討了鋁致神經細胞凋亡和程序性壞死的細胞信號通路和機制。并且采用阻斷手段驗證兩種細胞死亡方式的存在,尤其鋁致神經細胞程序性壞死是本項目的獨特發現,為國際首次。本項目在實驗室研究中探索了鋁降低神經突觸可塑性的機制和關鍵蛋白,并在鋁作業人群血液淋巴細胞得到驗證。由于人腦的不可及性,一般對認知功能損害只有用認知功能量表測試,無法探究損害機制;本項目發現鋁作業工人血液淋巴細胞tau蛋白過度磷酸化和降低神經突觸可塑性的信號通路蛋白分子,為研究人群認知功能損害提供了新的思路和方法,具有明顯創新性。本項目一個明顯特點是從人群發現問題,實驗室研究探索機制,再回到人群驗證。在職業環境中,工人以吸入多為納米級的鋁氧化物微細顆粒為主。而且納米氧化鋁越來越多地得到應用。本項目對納米氧化鋁的神經毒性、基因毒性及神經發育毒性進行了探討,為這一領域的研究進行了開創性的工作。本項目共發表SCI論文72篇,其中20篇代表性論文他引358次。項目帶頭人受邀多次在國際和國內學術會議作報告。論文對于闡明鋁導致認知功能損害作用機制提供了豐富而科學的依據,為科學家群體深入探討鋁的神經毒性及阿爾茲海默病病因和危險因素提供了資料,為保護鋁作業人群身體健康做出了貢獻。
四、主要支撐材料目錄(被引用論文題目及作者)
序號
論文題目
論文作者
1
Increased aluminum and lithium and decreased zinc levels in plasma is related to cognitive impairment in workers at an aluminum factory in China: A cross-sectional study
Shang, N (Shang, Nan); Zhang, L (Zhang, Lan); Wang, S (Wang, Shuo); Huang, T (Huang, Tao); Wang, YH (Wang, Yanhong); Gao, XC (Gao, Xiaocheng); Xu, SM (Xu, Shimeng); Zhang, JQ (Zhang, Jingqi); Zhang, L (Zhang, Ling); Niu, Q (Niu, Qiao); Zhang, QL (Zhang, Qinli)
2
Aluminum-Induced Cognitive Impairment and PI3K/Akt/mTOR Signaling Pathway Involvement in Occupational Aluminum Workers
Shang, N (Shang, Nan); Zhang, P (Zhang, Ping); Wang, S (Wang, Shuo); Chen, JP (Chen, Jianping); Fan, R (Fan, Rong); Chen, J (Chen, Jin); Huang, T (Huang, Tao); Wang, YH (Wang, Yanhong); Duncan, J (Duncan, Jeremy); Zhang, L (Zhang, Ling); Niu, Q (Niu, Qiao); Zhang, QL (Zhang, Qinli)
3
Aluminium-induced synaptic plasticity injury via the PHF8-H3K9me2-BDNF signalling pathway
Li, H (Li, Huan); Xue, XL (Xue, Xingli); Li, ZY (Li, Zhaoyang); Pan, BL (Pan, Baolong); Hao, YX (Hao, Yanxia); Niu, Q (Niu, Qiao)
4
Aluminum-Induced Synaptic Plasticity Impairment via PI3K-Akt-mTOR Signaling Pathway
Li, H (Li, Huan); Xue, XL (Xue, Xingli); Li, L (Li, Liang); Li, YQ (Li, Yaqin); Wang, YN (Wang, Yanni); Huang, T (Huang, Tao); Wang, YH (Wang, Yanhong); Meng, HX (Meng, Huaxing); Pan, BL (Pan, Baolong); Niu, Q (Niu, Qiao)
5
The Relationship between Plasma Al Levels and Multi-domain Cognitive Performance among In-service Aluminum-exposed Workers at the SH Aluminum Factory in China: A Cross-sectional Study
Wang, SS (Wang, Shanshan); Meng, HX (Meng, Huaxing); Shang, N (Shang, Nan); Guo, JH (Guo, Junhong); Zhang, T (Zhang, Ting); Zhang, SH (Zhang, Shuhui); Zhao, YQ (Zhao, Yuqing); Zhang, HF (Zhang, Huifang); Zhang, QL (Zhang, Qinli); Niu, Q (Niu, Qiao)
6
Exposure to Alumina Nanoparticles in Female Mice During Pregnancy Induces Neurodevelopmental Toxicity in the Offspring
Zhang, QL (Zhang, Qinli); Ding, Y (Ding, Yong); He, KH (He, Kaihong); Li, H (Li, Huan); Gao, FP (Gao, Fuping); Moehling, TJ (Moehling, Taylor J.); Wu, XH (Wu, Xiaohong); Duncan, J (Duncan, Jeremy); Niu, Q (Niu, Qiao)
7
Overview of the Relationship Between Aluminum Exposure and Health of Human Being
Niu, Q (Niu, Qiao)
8
Alumina at 50 and 13nm nanoparticle sizes have potential genotoxicity
Zhang, QL (Zhang, Qinli); Wang, HY (Wang, Haiyang); Ge, CC (Ge, Cuicui); Duncan, J (Duncan, Jeremy); He, KH (He, Kaihong); Adeosun, SO (Adeosun, Samuel O.); Xi, HX (Xi, Huaxin); Peng, HT (Peng, Huiting); Niu, Q (Niu, Qiao)
9
Caspase-3 is Involved in Aluminum-Induced Impairment of Long-Term Potentiation in Rats Through the Akt/GSK-3 beta Pathway
Zhang, HF (Zhang, Huifang); Yang, XJ (Yang, Xiaojuan); Qin, XJ (Qin, Xiujun); Niu, Q (Niu, Qiao)
10
The Relationship Between Cognitive Impairment and Global DNA Methylation Decrease Among Aluminum Potroom Workers
Yang, XJ (Yang, Xiaojuan); Yuan, YZ (Yuan, Yuzhou); Lu, XT (Lu, Xiaoting); Yang, J (Yang, Jin); Wang, LP (Wang, Linping); Song, J (Song, Jing); Nie, JS (Nie, Jisheng); Zhang, QL (Zhang, Qinli); Niu, Q (Niu, Qiao)
11
Effects of Aluminium on beta-Amyloid (1-42) and Secretases (APP-Cleaving Enzymes) in Rat Brain
Wang, LP (Wang, Linping); Hu, JL (Hu, Jiali); Zhao, Y (Zhao, Yue); Lu, XT (Lu, Xiaoting); Zhang, QL (Zhang, Qinli); Niu, Q (Niu, Qiao)
12
Cognitive Disorders and Tau-Protein Expression Among Retired Aluminum Smelting Workers
Lu, XT (Lu, Xiaoting); Liang, RF (Liang, Ruifeng); Jia, ZJ (Jia, Zhijian); Wang, H (Wang, Hao); Pan, BL (Pan, Baolong); Zhang, QL (Zhang, Qinli); Niu, Q (Niu, Qiao)
13
Effects of Exposure to Aluminum on Long-term Potentiation and AMPA Receptor Subunits in Rats in vivo
Song, J (Song Jing); Liu, Y (Liu Ying); Zhang, HF (Zhang Hui Fang); Zhang, QL (Zhang Qin Li); Niu, Q (Niu Qiao)
14
Caspase-3 Short Hairpin RNAs: A Potential Therapeutic Agent in Neurodegeneration of Aluminum-Exposed Animal Model
Zhang, QL (Zhang, Qinli); Li, N (Li, Na); Jiao, X (Jiao, Xia); Qin, XJ (Qin, Xiujun); Kaur, R (Kaur, Ramanjit); Lu, XT (Lu, Xiaoting); Song, J (Song, Jing); Wang, LP (Wang, Linping); Wang, JM (Wang, Junming); Niu, Q (Niu, Qiao)
15
Necrostatin-1 inhibits the degeneration of neural cells induced by aluminum exposure
Zhang, QL (Zhang Qinli); Li, MQ (Li Meiqing); Jiao, X (Jiao Xia); Xu, L (Xu Li); Guo, WL (Guo Weili); Ji, XL (Ji Xiuliang); Ji, JW (Ji Junwei); Yang, HL (Yang Hailan); Zhang, C (Zhang Ce); Niu, Q (Niu Qiao)
16
Aluminium-Maltolate-induced Impairment of Learning, Memory and Hippocampal Long-term Potentiation in Rats
Liang, RF (Liang, Rui-feng); Li, WQ (Li, Wei-qing); Wang, XH (Wang, Xiao-hui); Zhang, HF (Zhang, Hui-fang); Wang, H (Wang, Hong); Wang, JX (Wang, Jun-xia); Zhang, Y (Zhang, Yu); Wan, MT (Wan, Ming-tao); Pan, BL (Pan, Bao-long); Niu, Q (Niu, Qiao)
17
APP/PS1 TRANSGENIC MICE TREATED WITH ALUMINUM: AN UPDATE OF ALZHEIMER'S DISEASE MODEL
Zhang, QL (Zhang, Q. L.); Jia, L (Jia, L.); Jiao, X (Jiao, X.); Guo, WL (Guo, W. L.); Ji, JW (Ji, J. W.); Yang, HL (Yang, H. L.); Niu, Q (Niu, Q.)
18
IN VIVO TOXICITY OF NANO-ALUMINA ON MICE NEUROBEHAVIORAL PROFILES AND THE POTENTIAL MECHANISMS
Zhang, QL (Zhang, Q. L.); Li, MQ (Li, M. Q.); Ji, JW (Ji, J. W.); Gao, FP (Gao, F. P.); Bai, R (Bai, R.); Chen, CY (Chen, C. Y.); Wang, ZW (Wang, Z. W.); Zhang, C (Zhang, C.); Niu, Q (Niu, Q.)
19
NOVEL INTERVENTIONS TARGETING ON APOPTOSIS AND NECROSIS INDUCED BY ALUMINUM CHLORIDE IN NEUROBLASTOMA CELLS
Zhang, QL (Zhang, Q. L.); Niu, Q (Niu, Q.); Niu, PY (Niu, P. Y.); Ji, XL (Ji, X. L.); Zhang, C (Zhang, C.); Wang, L (Wang, L.)
20
BAX GENE SILENCING: A POTENTIAL INTERVENTION IN ALUMINUM-INDUCED NEURAL CELL DEATH
Zhang, QL (Zhang, Q. L.); Niu, Q (Niu, Q.); Niu, PY (Niu, P. Y.); Shi, YT (Shi, Y. T.); Liu, CY (Liu, C. Y.); Di Gioacchino, M (Di Gioacchino, M.); Zhang, L (Zhang, L.); Zhang, C (Zhang, C.); Braga, M (Braga, M.)
五、主要完成人及完成單位情況
六、主要完成單位及排名情況