暢瑞苗
醫學博士學位，副教授，碩士生導師，藥物分析教研室
E-mail: chang5013@126.com
教育經歷
2013年9月—2016年12月 西安交通大學，博士
2010年9月—2013年7月 c7c7.app，碩士
2006年9月—2010年7月 c7c7.app，學士
工作經歷
2023年12月—今 c7c7.app 副教授
2022年3月—今 山西白求恩醫院 博士后
2016年12月—2023年12月 c7c7.app 講師
學術任職
雜志《西北藥學》、《Nano Biomedicine and Engineering》青年編委。
榮譽獲獎
全國醫學類微課教學比賽三等獎。
教學情況
主要承擔研究生《現代藥物分析方法與技術》、本科生《藥物分析》理論及實驗課程、本科生《中藥制劑分析》實驗課程、藥學專升本《藥物分析》理論課程的教學。
研究領域
主要從事基于miRNA中藥活性成分篩選及心腎藥效研究、中藥活性成分分離分析、難溶性藥物增溶等方面的科研工作。
代表性科研、教改項目
1、黃芪調控miR-21活性物質的快速發現及其對心肌纖維化ERK-MAPK通路的影響，中國博士后科學基金第73批面上資助，8萬元。項目負責人，在研。
2、黃芪中靶向miR-21成熟過程關鍵核酸的活性成分快速發現及其抗心衰作用研究，國家自然科學基金（青年），30萬元。項目負責人，在研。
3、以mi-RNA 21為靶點的黃芪抗心衰活性組分可視化垂釣新方法構建。山西省基礎研究計劃，5萬元。項目負責人，結題。
4、c7c7.app教育教學研究課題，一般性課題：基于OBE理念的藥學本科畢業論文指導方法研究與實踐，項目負責人，在研。
5、環境暴露微血管病變防治，山西省科技創新人才團隊（青年），100萬元。項目核心人員，在研。
6、基于新型“雙增敏”策略的樣品前處理技術耦合SFC-MS的FAHFAs分析體系構建，山西省基礎研究計劃面上項目，10萬元。項目核心人員，在研。
7、基于新型功能化離子液體的HPCE分離體系研究及其在臨床手性藥物分析中的應用，山西省衛生健康委員會醫學重點科技項目，15萬元。項目核心人員，結題。
代表性論著
1. Ruimiao Chang#, Xinying Qu#, Yuting Ye, Ying Qu, Bingyang Chu*, Zhiyong Qian*. Current advances in nanomedicine-based therapies for acute kidney injury. Chinese Chemical Letters, 2024, 394, 110802.
2. Ruimiao Chang, Huichun Wang, Shumian Liu, Yijing Dong, Guangbin Zhang, Anjia Chen, Ruiping Zhang*, Yong Li*. Modifying of magnetic UiO-66-NH2 as a new nanosorbent by thermo-alkali-hydrolysis technology for highly efficient enrichment and determination of quercetin in apple peel[J]. Separation and Purification Technology, 2025, 353: 128054.
3. Meiyi Wang, Junzhao Ren, Guangbin Zhang, Hongfen Zhang, Ruimiao Chang, Haixia Yu*, Anjia Chen*. Simultaneous separation and determination of seven biphenyl cyclooctene lignans in Schisandra chinensis and its preparations by micellar electrokinetic chromatography with dual organic solvent system[J]. Phytochemical Analysis, 2024;1-10.
4. 暢瑞苗, 張艷洋, 康安娟, 張廣彬, 余彥平, 任俊照, 陳安家, 李勇. 熱堿解改性UiO-66材料對槲皮素的裝載、釋放及抗氧化作用研究[J]. 藥學學報, 2023, 58(9): 2802-2810.
5. Rui Miao Chang, Yan Yang Zhang, Guang Bin Zhang, Xiao Xia Zhang, An Jia Chen, Wen Zhang, Yong Li. Application of thermal alkaline hydrolysis technology to improve the loading and in-vitro release of gallic acid in UiO-66[J]. Food Chemistry, 2022, 391: 133238.
6. Hua Wang#, Yuhang Yang#, Jing Guo, Mengli Wang, Hongfen Zhang, Guangbin Zhang, Ruimiao Chang*, Anjia Chen*. Simultaneous separation and determination of four active ingredients in Picria fel-terrae Lour. and its preparations by micellar electrokinetic chromatography[J]. Phytochemical Analysis, 2021, 32(6): 1110-1117.
7. Yang Yuhang#, Wang Hua#, Yu Haixia, Zhang Hongfen, Zhang Guangbin, Chang Ruimiao*, Chen Anjia*. Simultaneous separation and determination of three huperzine alkaloids in Huperzia serrata and its preparations by cyclodextrin-modified mixed micellar electrokinetic capillary chromatography[J]. Analytical Biochemistry, 2021, 623: 114207.
8. Mengli Wang, Jing Guo, Zhiying Wang, Guangbin Zhang, Haixia Yu, Ruimiao Chang*, Anjia Chen*. Simultaneous separation and determination of hirsutine and hirsuteine by cyclodextrin-modified micellar electrokinetic capillary chromatography[J]. Phytochemical analysis. 2020, 31: 112-118.
9. Haitao Guo, Zhiying Wang, Liying Xu, Hongfen Zhang, Ruimiao Chang*, Anjia Chen*. Separation and simultaneous determination of seven bioactive components in, Tripterygium wilfordii, Hook.F. and, Tripterygium, preparations by micellar electrokinetic capillary chromatography[J]. Electrophoresis 2019, 40, 547-554.
10. Jing Guo, Mengli Wang, Haitao Guo, Ruimiao Chang, Haixia Yu, Guangbin Zhang*, Anjia Chen*. Simultaneous separation and determination of seven isoflavones in Radix Puerariae by capillary electrophoresis with a dual cyclodextrin system[J]. Biomedical Chromatography. 2019; e4646.
11. Zhiying Wang, Haitao Guo, Meng Chen, Guangbin Zhang, Ruimiao Chang*, Anjia Chen*. Separation and determination of corynoxine and corynoxine b using chiral ionic liquid and hydroxypropyl-β-cyclodextrin as additives by field-amplified sample stacking in capillary electrophoresis[J], Electrophoresis, 2018, 39(17): 2195-2201.
12. Ruimiao Chang, Qiang Fu, Yong Li, Mingchan Wang, Wei Du, Chun Chang, Aiguo Zeng*. Crystallization and relaxation dynamics of amorphous loratadine under different quench-cooling temperatures[J]. CrystEngComm, 2017, 19(2): 335-345.
13. Ruimiao Chang, Qiang Fu, Pei Yu, Lu Wang, Wei Du, Chun Chang, Aiguo Zeng*. A new polymorphic form and polymorphic transformation of loratadine[J]. RSC Advances, 2016, 6(88): 85063-85073.
14. Ruimiao Chang, Aiguo Zeng, Wei Du, Xinya Xu, Saijie Zuo, Chun Chang, Qiang Fu*. An HPLC method for the determination of a novel anti-hypertension agent 6,7-dimethoxy-3-(4-(4-fluorobenzyloxy)-3-methoxyphenylmethyl) quinazolin-4(3H)-one in rat plasma: application to pharmacokinetic study[J]. Biomedical Chromatography, 2016, 30(7): 1118-1123.
15. Chen M, Chang RM, Xu LY, Huang YY, Zhang HF*, Chen AJ*. Simultaneous separation and determination of praeruptorin A, B and C by micellar electrokinetic chromatography using sodium dodecyl sulfate and sodium cholate as mixed micelles[J]. Phytochemical Analysis, 2018, 29(5): 425-431.
16. Xu LY, Chang RM, Chen M, Li L, Huang YY, Zhang HF*, Chen AJ*. Quality evaluation of Guan-Xin-Ning injection based on fingerprint analysis and simultaneous separation and determination of seven bioactive constituents by capillary electrophoresis[J]. Electrophoresis, 2017, 38(24): 3168-3176.
17. Wang J, Chang RM, Zhang JY, Zhang T, Fu Q, Chang C, Zeng AG*. Coamorphous loratadine-citric acid system with enhanced physical stability and bioavailability[J]. AAPS PharmSciTech, 2017: 1-10.
