郭曉敏

c7c7.app藥學院，講師，博士

E-mail: guoxiaomin1@sxmu.edu.cn

教育經歷

2020年9月—2024年6月 蘭州大學，博士

2017年9月—2020年6月 蘭州大學，碩士

2013年9月—2017年6月 大連醫科大學，學士

工作經歷

2024年8月至今 c7c7.app，藥學院，講師

榮譽獲獎

2024年甘肅省優秀畢業生

2024年甘肅省優秀博士學位論文

研究領域

生物活性肽與微生物感染，新型抗菌肽的優化設計及對細菌生物膜的活性和機制研究

代表性論著

1. Xiaomin Guo#, Xiaokang Miao#, Yingying An, Tiantian Yan, Yue Jia, Bochuan Deng, Jianfeng Cai, Wenle Yang, Wangsheng Sun*, Rui Wang*, and Junqiu Xie*. Novel antimicrobial peptides modified with fluorinated sulfono-γ-AA having high stability and targeting multidrug-resistant bacteria infections. European Journal of Medicinal Chemistry. 2024; 264: 116001. （中科院二區，IF = 5.9）

2. Yingying An#, Xiaomin Guo#, Tiantian Yan, Yue Jia, Ruoyan Jiao, Xinyu Cai, Bochuan Deng, Guangjun Bao, Yiping Li, Wenle Yang, Rui Wang*, Wangsheng Sun*, Junqiu Xie*. Enhancing the stability and therapeutic potential of the antimicrobial peptide Feleucin-K3 against multidrug-resistant A. baumannii through rational utilization of a D-amino acid substitution strategy. Biochemical Pharmacology. 2024, 225, 116269. （中科院二區，IF = 5.3）（共同第一作者）

3. Xiaomin Guo, Tiantian Yan, Jing Rao, Yingying An, Xin Yue, Xiaokang Miao, Rui Wang, Wangsheng Sun*, Jianfeng Cai*, Junqiu Xie*. Novel Feleucin-K3-derived peptides modified with sulfono-γ-AA building blocks targeting Pseudomonas aeruginosa and MRSA infections. Journal of Medicinal Chemistry. 2023, 66(2): 1254?1272. （中科院一區，IF = 6.8）

4 Xiaomin Guo, Tiantian Yan, Jing Rao, Xin Yue, Xiong Pei, Jiahui Deng, Wangsheng Sun, Wenle Yang, Bangzhi Zhang, Junqiu Xie*. Potent antimicrobial and antibiofilm activities of Feleucin-K3 analogs modified by α-(4-Pentenyl)-Ala against multidrug-resistant bacteria. Biomolecules. 2021, 11(5): 761. （中科院二區，IF = 4.8）

5. Xiaomin Guo#, Jing Rao#, Tiantian Yan, Bangzhi Zhang, Wenle Yang, Wangsheng Sun*, Junqiu Xie*. Feleucin-K3 Analogue with an α-(4-Pentenyl)-Ala substitution at the key site has more potent antimicrobial and antibiofilm activities in vitro and in vivo. ACS Infectious Diseases. 2021, 7: 64-78. （中科院二區，IF = 4.0）

6. Guangjun Bao, Peng Wang, Xiaomin Guo, Yiping Li, Zeyuan He, Xinyi Song, Ruiyao E, Tingli Yu, Junqiu Xie*, Wangsheng Sun*. Visible-light mediated deoxygenation of carboxylic acid for late-stage peptide modification targeting dehydroalanine. Organic Letters. 2023, 25(46): 8338-8343.（中科院一區，IF = 4.9）