任鵬璇
藥物化學(xué)教研室 講師 博士
E-mail: rpxsmkx@163.com
個(gè)人主頁(yè)或網(wǎng)站：https://www.researchgate.net/profile/Pengxuan-Ren
教育經(jīng)歷
2019年9月—2024年7月 上?？萍即笱?，碩博連讀
2014年9月—2018年7月 中國(guó)藥科大學(xué)，學(xué)士
工作經(jīng)歷
2024年8月—至今 c7c7.app 講師
研究領(lǐng)域
計(jì)算生物學(xué)、人工智能、藥物設(shè)計(jì)。致力于針對(duì)關(guān)鍵藥物靶標(biāo)，應(yīng)用計(jì)算機(jī)輔助藥物設(shè)計(jì)方法和人工智能算法發(fā)現(xiàn)和設(shè)計(jì)藥物。
代表性科研、教改項(xiàng)目
1、科技部, 國(guó)家重點(diǎn)研發(fā)計(jì)劃, 2020YFA0509700, 植物隱花色素蛋白機(jī)器光反應(yīng)的分子動(dòng)態(tài)機(jī)制研究,2020-11 至 2025-10, 90萬(wàn)元, 參與。
2、上海市科委, 青年科技啟明星, 20QA1406400, 基于分子片段的蛋白質(zhì)-蛋白質(zhì)作用調(diào)控劑的設(shè)計(jì)方法,2020-06 至 2023-05, 40萬(wàn)元, 參與。
代表性論著
1、Pengxuan Ren; Weijuan Shang; Wanchao Yin; Huan Ge; Lin Wang; Xianglei Zhang; Bingqian Li; Honglin Li; Yechun Xu; Eric H Xu; Hualiang Jiang; Lili Zhu; Leike Zhang; Fang Bai ; A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors, Acta Pharmacologica Sinica, 2022, 43(2): 483-493.
2、Pengxuan Ren; Changyue Yu; Ruxue Zhang; Tianqing Nie; Qiaoyu Hu; Hui Li; Xianglei Zhang; Xueyuan Zhang; Shiwei Li; Lu Liu; Wenhao Dai; Jian Li; Yechun Xu; Haixia Su; Leike Zhang; Hong Liu; Fang Bai ; Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2, European Journal of Medicinal Chemistry, 2023, 249: 115129.
3、Pengxuan Ren; Hui Li; Tianqing Nie; Xiaoqin Jian; Changyue Yu; Jian Li; Haixia Su; Xianglei Zhang; Shiwei Li; Xin Yang; Chao Peng; Yue Yin; Leike Zhang; Yechun Xu; Hong Liu; Fang Bai ; Discovery and mechanism study of SARS-CoV-2 3C-Like protease inhibitors with a new reactive group, Journal of Medicinal Chemistry, 2023, 66(17): 12266-12283.
4、Pengxuan Ren; Shiwei Li; Shihang Wang; Xianglei Zhang; Fang Bai ; Computer-aided prediction of the interactions of viral proteases with antiviral drugs: antiviral potential of broad-spectrum drugs, Molecules, 2023, 29(1): 225-225.
5、Zongquan Li; Pengxuan Ren; Hao yang; Jie Zheng; Fang Bai ; TEFDTA: a transformer encoder and fingerprint representation combined prediction method for bonded and non-bonded drug-target affinities, Bioinformatics, 2023, 40(1): btad778.
6、Sanjeev Kiran Gotru; Elmina Mammadova-Bach; Georgios Sogkas; Michael K. Schuhmann; Karen Schmitt; Peter Kraft; Sabine Herterich; Medina Mamtimin; Akif Pinarci; Sarah Beck; Simon Stritt; Han Chao; Pengxuan Ren; Jean-Noël Freund; Christian Klemann; Felix C. Ringshausen; Johan W.M. Heemskerk; Alexander Dietrich; Bernhard Nieswandt; Guido Stoll; Thomas Gudermann; Attila Braun ; MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice, Arteriosclerosis, Thrombosis, and Vascular Biology, 2023, 48(8): 1494-1509.
