9. 國家自然科學基金面上項目，81872210，Hsa_circ_0089466致ERK通路激活對喉鱗癌干細胞干性維持及化療抵抗的作用與機制研究，2019.01-2022.12，55萬，在研，第二參與人

10. 國家自然科學基金青年基金，81802948，長鏈非編碼RNA REG1CP上調TNF-α激活TGF-β通路介導喉鱗癌侵襲轉移的機制研究，2019.01-2021.12，17萬，在研，第十參與人

11. 國家自然科學基金青年基金，31201940，Ipr1基因介導巨噬細胞凋亡的作用機制研究，2013.01-2015.12，21萬，已結題，第二參與人

12. 國家自然科學基金青年基金，31302046，ZFP57與?？寺∨哂〖；蛞斐Ｈゼ諄墓叵笛芯?，2014.01-2016.12，25萬，已結題，第三參與人

13. 國家自然科學基金面上項目，31472094，牛胚胎發育相關精子特異miRNAs的鑒定和功能研究，2015.01-2018.12，87萬，已結題，第三參與人

14. 山西省優秀人才科技創新項目, 201605D211029, microRNA調控糖酵解關鍵分子介導代謝重塑在喉鱗癌侵襲轉移及放化療抵抗中的機制與臨床意義，2017.01-2019.12，15萬，已結題，第四參與人

15. 山西省科技成果轉化引導專項項目, 201804D131043,適宜臨床醫學研究中心等重點科技創新平臺的科研綜合業務智能管理系統研發與推廣，2018.06-2020.12，30萬，在研，第三參與人

代表性論文

1. Yongyan Wu#, Yuliang Zhang#, Xiwang Zheng#, Fengsheng Dai#, Yan Lu#, Li Dai, Min Niu, Huina Guo, Wenqi Li, Xuting Xue, Yunfeng Bo, Yujia Guo, Jiangbo Qin, Yixiao Qin, Hongliang Liu, Yu Zhang, Tao Yang, Li Li, Linshi Zhang, Rui Hou, Shuxin Wen, Changming An*, Huizheng Li*, Wei Xu*, Wei Gao*, Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/PBX3 axis,Molecular Cancer, 2020, 19(1):99(大類TOP1區，IF=15.302，第一作者)

2. Yongyan Wu#, Yuliang Zhang#, Min Niu#, Yong Shi#, Hongliang Liu, Dongli Yang, Fei Li, Yan Lu, Yunfeng Bo, Ruiping Zhang, Zhenyu Li, Hongjie Luo, Jiajia Cui, Jiangwei Sang, Caixia Xiang, Wei Gao*, Shuxin Wen*, Whole-Transcriptome Analysis of CD133＋CD44＋Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma Cells,Cellular Physiology and Biochemistry, 2018, 47(4): 1696-1710 (大類2區，IF=5.5，第一作者)

3. Wei Gao#, Huina Guo#, Min Niu, Xiwang Zheng, Yuliang Zhang, Xuting Xue, Yunfeng Bo, Xiaoya Guan, Zhongxun Li, Yujia Guo, Long He, Yu Zhang, Li Li, Jimin Cao,Yongyan Wu*, circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway,Molecular Cancer, 2020, 19(1):166(大類TOP1區, IF=15.302,通信作者)

4. Wei Gao#, Yuliang Zhang#, Hongjie Luo#*, Min Niu#, Xiwang Zheng#, Wanglai Hu, Jiajia Cui, Xuting Xue, Yunfeng Bo, Fengsheng Dai, Yan Lu, Dongli Yang, Yujia Guo, Huina Guo, Huizheng Li, Yu Zhang, Tao Yang, Li Li, Linshi Zhang, Rui Hou, Shuxin Wen*, Changming An*, Teng Ma*, Lei Jin*, Wei Xu*,Yongyan Wu*, Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1–AKT axis-mediated glycolysis, Cell death & disease, 2020, 11(10): 919 (大類2區, IF=6.304,通信作者)

5. Fengsheng Dai#, Li Dai#, Xiwang Zheng, Yujia Guo, Yuliang Zhang, Min Niu, Yan Lu, Huizheng Li, Rui Hou, Yu Zhang, Shuxin Wen, Wanglai Hu, Changming An*,Yongyan Wu*, Wei Gao*, Non-coding RNAs in drug resistance of head and neck cancers: A review,Biomedicine & Pharmacotherapy, 2020, 127: 110231(大類TOP3區，IF=4.545，共同通信作者)

6. Qinli Zhao#, Xiwang Zheng#, Huina Guo, Xuting Xue, Yuliang Zhang, Min Niu, Jiajia Cui, Hongliang Liu, Hongjie Luo, Dongli Yang, Yong Shi, Hui Huangfu, Shuxin Wen,Yongyan Wu*, Wei Gao*, Serum Exosomal miR-941 as a promising Oncogenic Biomarker for Laryngeal Squamous Cell Carcinoma,Journal of Cancer, 2020, 11(18): 5329-5344 (大類3區，IF=3.565，共同通信作者)

7. Gao W#, Zhang C#, Li W#, Li H#, Sang J#, Zhao Q, Bo Y, Luo H, Zheng X, Lu Y, Shi Y, Yang D, Zhang R, Li Z, Cui J, Zhang Y, Niu M, Li J, Wu Z, Guo H, Xiang C, Wang J, Hou J, Zhang L, Thorne RF*, Cui Y*,Wu Y*, Wen S*, Wang B*, Promoter Methylation-Regulated miR-145-5p Inhibits Laryngeal Squamous Cell Carcinoma Progression by Targeting FSCN1,Molecular Therapy, 2019, 27(2): 365-379(大類TOP1區，IF=8.986，ESI高被引論文，共同通信作者)

8. Kun Song#, Qian Li#, Wei Gao#, Shaoyong Lu#, Qiancheng Shen, Xinyi Liu,Yongyan Wu, Houwen Lin, Guoqiang Chen, Jian Zhang*, AlloDriver: a method for the identification and analysis of cancer driver targets,Nucleic Acids Research, 2019, 47(W1): W315-W321(大類TOP1區，IF=11.501，共同作者)

9. Hamed Yari#, Lei Jin#, Liu Teng, Yufang Wang,Yongyan Wu, Guang Zhi Liu, Wei Gao, Jin Liang, Yanfeng Xi, Yu Chen Feng, Chunming Zhang, Yuan Yuan Zhang, Hessam Tabatabaee, Ting La, Rui Hong Yang, Fu Hua Wang, Xu Guang Yan, Margaret Farrelly, Rodney Scott, Tao Liu, Rick F. Thorne, Su Tang Guo*, Xu Dong Zhang*, LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription,Nature Communications, 2019, 10(5334): 1-15 (大類TOP1區，IF=12.121，共同作者)

10. Wei Gao#, Yuliang Zhang#, Min Niu#, Yunfeng Bo, Huizheng Li, Xuting Xue, Yan Lu, Xiwang Zheng, Yemei Tang, Jiajia Cui, Long He, Rick F.Thorne*,Yongyan Wu*, Identification of miR-145-5p-centered competing endogenous RNA network in laryngeal squamous cell carcinoma,Proteomics, 2019, 6(21-22): e1900020 (大類2區，IF=3.254，通信作者)

11. Wei Gao#, Changming An#, Xuting Xue#, Xiwang Zheng#, Min Niu, Yuliang Zhang, Hongliang Liu, Chunming Zhang, Yan Lu, Jiajia Cui, Qinli Zhao, Shuxin Wen, Rick F.Thorne, Xudong Zhang*,Yongyan Wu*, Mass Spectrometric Analysis Identifies AIMP1 and LTA4H as FSCN1 Binding Proteins in Laryngeal Squamous Cell Carcinoma,Proteomics, 2019, 19(21-22): e1900059 (大類2區，IF=3.254，共同通信作者)

12. Wei Gao#,Yongyan Wu#, Xiaoling He, Chunming Zhang, Meixia Zhu, Bo Chen, Qingqing Liu, Xukuan Qu, Weiyan Li, Shuxin Wen*, MicroRNA-204-5p inhibits invasion and metastasis of laryngeal squamous cell carcinoma by suppressing forkhead box C1,Journal of Cancer, 2017, 8(12): 2356-2368 (大類3區，IF=3.565，并列第一作者)

13. Yujun Li#, Jie Liu#, Wanglai Hu#, Yuliang Zhang#, Jiangwei Sang, Huizheng Li, Teng Ma, Yunfeng Bo, Tao Bai,, Huina Guo, Yan Lu, Xuting Xue, Min Niu, Shanshan Ge, Shuxin Wen, Wei Gao*,Yongyan Wu*, miR-424-5p Promotes Proliferation, Migration and Invasion of Laryngeal Squamous Cell Carcinoma,Oncotargets and Therapy, 2019, 12: 10441-10453 (大類3區，IF=3.337，通信作者)

14. Dongli Yang#, Yong Shi#, Yemei Tang#, Hongyu Yin, Yujia Guo, Shuxin Wen, Bingquan WANG, Changming An,Yongyan Wu*, Wei Gao*, Effect of HPV infection on the occurrence and development of laryngeal cancer: a review,Journal of Cancer, 2019, 10(19): 4455-4462 (大類3區，IF=3.565，共同通信作者)

15. Hongliang Liu#, Jiajia Cui, Yuliang Zhang, Min Niu, Xuting Xue, Hongyu Yin, Yemei Tang, Li Dai, Fengsheng Dai, Yujia Guo,Yongyan Wu*, Wei Gao*, Mass spectrometry-based proteomic analysis of FSCN1-interacting proteins in laryngeal squamous cell carcinoma cells,IUBMB Life, 2019, 71(11): 1771-1784 (大類3區，IF=3.244，共同通信作者)

16. Jiajia Cui#, Xiwang Zheng#, Dongli Yang#, Yinghuan Hu, Changming An, Yunfeng Bo, Huizheng Li, Yuliang Zhang, Min Niu, Xuting Xue, Yan Lu, Yemei Tang, Hongyu Yin, Zhenyu Li, Wei Gao*,Yongyan Wu*, Astragali radix total flavonoid synergizes cisplatin to inhibit proliferation and enhances the chemosensitivity of laryngeal squamous cell carcinoma,Rsc Advances, 2019, 9(42): 24471-24482 (大類分區3區，IF=3.119，通信作者)

17. Jue Wang#,Yongyan Wu#, Wei Gao#, Fei Li, Yunfeng Bo, Meixia Zhu, Rong Fu, Qingqing Liu, Shuxin Wen*, Identification and characterization of CD133＋CD44＋cancer stem cells from human laryngeal squamous cell carcinoma cell lines,Journal of Cancer, 2017, 8(3): 497-506 (大類3區，IF=3.565，共同第一作者)

18. Yongyan Wu#, Zekun Guo, KezhenYao, Yue Miao, Shuxin Liang, Fayang Liu, Yongsheng Wang, Yong Zhang*, The Transcriptional Foundations of Sp110-mediated Macrophage（RAW264.7）Resistance to Mycobacterium tuberculosis H37Ra,Scientific Reports, 2016, 6: 22041 (大類3區，IF=4.011，第一作者)

19. Yongyan Wu#, Fayang Liu, Yan Zhang, Yongsheng Wang, Zekun Guo, Yong Zhang*, Characterization of promoter of the tuberculosis-resistant gene intracellular pathogen resistance 1,Immunologic Research, 2016, 64(1): 143-154 (大類3區，IF=2.610，第一作者)

20. Yongyan Wu#, Fayang Liu, Yingying Liu, Xiaolei Liu, Zhiying Ai, Zekun Guo, Yong Zhang*, GSK3 inhibitors CHIR99021 and 6-bromoindirubin-39-oxime inhibit microRNA maturation in mouse embryonic stem cells,Scientific Reports, 2015(5): 8666 (大類3區，IF=4.011，第一作者)

21. Yongyan Wu#, Zhiying Ai, Kezhen Yao, Lixia Cao, Juan Du, Xiaoyan Shi, Zekun Guo*, Yong Zhang*, CHIR99021 promotes self-renewal of mouse embryonic stem cells by modulation of protein-encoding gene and long intergenic non-coding RNA expression,Experimental Cell Research, 2013, 319(17): 2684-2699 (大類2區，IF=3.329，第一作者)

22. Yongyan Wu#, Yong Zhang*, SUMOylation Represses Nanog Expression via Modulating Transcription Factors Oct4 and Sox2,PloS One, 2012, 7(6): e39606 (大類3區，IF=2.776，第一作者)

著作與教材

第一主編，臨床醫學檢驗理論基礎和實踐操作，科學技術文獻出版社，720千字，2018

會議論文

1. 吳勇延，高偉，張春明，溫樹信，張璐，屈旭寬，郭慧娜，王娟*，SKA3介導PI3K/Akt通路調控糖酵解代謝在喉鱗癌侵襲轉移中的機制研究，中華醫學會第十五次全國耳鼻咽喉頭頸外科學術會議，廈門市，中國，2017.10.13-10.15（壁報交流）

2. 高偉，陳文杰，張春明，吳勇延，趙沁麗，溫樹信，皇甫輝*，山西省1234例喉癌流行病學特征分析，中華醫學會第十五次全國耳鼻咽喉頭頸外科學術會議，廈門市，中國，2017.10.13-10.15（分會場發言）

3. 高偉，吳勇延*，環狀RNA circPARD3通過PRKCI-AKT-mTOR信號軸抑制自噬并促進喉鱗癌惡性進展和化療抵抗,中華醫學會第十七次全國耳鼻咽喉頭頸外科學術會議,上海市,中國, 2020.11.27-11.28（分會場發言）

4. 吳勇延,代豐升,張宇良,鄭希望,代力,牛敏,薛緒亭,郭慧娜,高偉*, miRNA-1207-5p靶向下調SKA3抑制喉鱗癌增殖與轉移的研究,中華醫學會第十七次全國耳鼻咽喉頭頸外科學術會議,上海市,中國, 2020.11.27-11.28（壁報交流）

知識產權

1. 第一發明人，一種慢病毒單質粒體內生物素化載體及制備方法，2019.11.19，中國，ZL 201610928951.4，發明專利

2. 第一發明人，可調節的瓊脂糖凝膠回收切膠器，2019.10.18，中國，ZL 201930041826.6，外觀專利

3. 第一發明人，一種帶UV紫外線燈的離心管架，2016.08.31，中國，ZL 201620339275.2，實用新型專利

4. 第一發明人，一種搖床，2019.11.22，中國，ZL 201920109376.4，實用新型專利

5. 第二發明人，一種細胞平板克隆形成圖像采集儀，2016.03.30，中國，ZL 201520998317.9，實用新型專利

6. 第二發明人，一種可調節的瓊脂糖凝膠回收切膠器，2019.10.18，中國，ZL 201920124174.7，實用新型專利

7. 第二發明人，搖床，2019.06.21，中國，ZL 201930036349.4，外觀專利

8. 第三發明人，一種尸頭解剖固定架，2019.02.19，中國，ZL 201820029259.2，實用新型專利

9. 第三發明人，尸頭解剖固定架，2018.06.19，中國，ZL 201830007713.X，外觀專利

10. 第一權利人，c7c7.app第一醫院，實驗室實驗技能在線考試管理系統，2019SR0947048，原始取得，全部權利，2019.09.11，軟件著作權

11. 第二權利人，科研業務綜合管理系統V5.0，2016SR107789，原始取得，全部權利，2016.05.17，軟件著作權

12. 第二權利人，c7c7.app第一醫院，山西方是科技有限公司，科研綜合業務云智慧管理系統，2019SR0262022，原始取得，全部權利，2019.03.19，軟件著作權

13. 第三權利人，頭頸腫瘤轉錄組與隨訪數據管理系統V1.0，2019SR0807557，原始取得，全部權利，2019.08.02，軟件著作權

科研獲獎

1. 第三獲獎人，喉鱗癌轉錄組差異網絡構建與關鍵生物學功能調控機制研究，山西省科學技術獎（自然科學類）一等獎，2019.03

2. 第十獲獎人，牛羊基因定點精確編輯技術，陜西省科學技術獎一等獎，2016.02